Registered Nurse Salary in St. Louis
2026 compensation data for Registered Nurse positions in St. Louis, MO. Ranges from $51,000 (entry-level) to $120,000 (senior). Median: $78,000.
Median (Mid)
$78,000
$37.5/hr
vs National
+4%
US: $75,000
COL Index
92
vs US avg = 100
Senior Max
$120,000
Top of band
Salary Ranges by Experience Level
Detailed Compensation Breakdown
| Level | Annual Min | Annual Median | Annual Max | Hourly (Median) |
|---|---|---|---|---|
| Entry-Level (0–2 yrs) | $51,000 | $59,000 | $69,000 | $28.37/hr |
| Mid-Level (3–5 yrs) | $66,000 | $78,000 | $92,000 | $37.5/hr |
| Senior (6+ yrs) | $87,000 | $101,000 | $120,000 | $48.56/hr |
What Your Salary Is Really Worth in St. Louis
A mid-level registered nurse earning $78,000 in St. Louis has the same buying power as $85,000 in an average US city, after adjusting for the local cost of living (COL index 92).
Cost of living comparisons use a base of 100 (US national average). Higher index = higher housing, transport, and consumer prices.
About Registered Nurse Salaries in St. Louis
The median registered nurse salary in St. Louis, MO is $78,000 for mid-level professionals, which is 4% above the national median. With a cost of living index of 92 (national average = 100), St. Louis offers an affordable cost of living, making these salaries stretch further.
Entry-level registered nurses in St. Louis can expect to earn between $51,000 and $69,000 (about $28.37/hour), while senior professionals with 6+ years of experience earn up to $120,000 ($120K annually, or about $57.69/hour).
These figures represent base salary only and do not include bonuses, equity, or benefits, which can add 20–50% to total compensation — especially at technology companies and in competitive markets like St. Louis.
Frequently Asked Questions: Registered Nurse Salary in St. Louis
What is the average Registered Nurse salary in St. Louis?+
The average Registered Nurse salary in St. Louis is $78,000 for a mid-level professional (3–5 years of experience). Entry-level pay starts around $59,000 and senior-level pay reaches $101,000.
How much does an entry-level registered nurse make in St. Louis?+
Entry-level registered nurses in St. Louis earn between $51,000 and $69,000, with a median of $59,000 per year (about $28.37/hour).
What is the hourly rate for a Registered Nurse in St. Louis?+
Based on a 2,080-hour work year, a Registered Nurse in St. Louis earns roughly $28.37/hour at entry-level, $37.5/hour at mid-level, and $48.56/hour at senior-level.
Is the Registered Nurse salary in St. Louis higher than the US average?+
Yes — Registered Nurse salaries in St. Louis are about 4% higher than the US national median of $75,000.
Does this include bonuses or equity?+
No — these figures are base salary only. Total compensation (base + bonus + equity + benefits) is typically 20–50% higher, and can be 2–3x at top technology and finance employers.
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