Nurse Practitioner Salary in St. Louis
2026 compensation data for Nurse Practitioner positions in St. Louis, MO. Ranges from $87,000 (entry-level) to $166,000 (senior). Median: $120,000.
Median (Mid)
$120,000
$57.69/hr
vs National
+2%
US: $118,000
COL Index
92
vs US avg = 100
Senior Max
$166,000
Top of band
Salary Ranges by Experience Level
Detailed Compensation Breakdown
| Level | Annual Min | Annual Median | Annual Max | Hourly (Median) |
|---|---|---|---|---|
| Entry-Level (0–2 yrs) | $87,000 | $99,000 | $112,000 | $47.6/hr |
| Mid-Level (3–5 yrs) | $106,000 | $120,000 | $136,000 | $57.69/hr |
| Senior (6+ yrs) | $129,000 | $145,000 | $166,000 | $69.71/hr |
What Your Salary Is Really Worth in St. Louis
A mid-level nurse practitioner earning $120,000 in St. Louis has the same buying power as $130,000 in an average US city, after adjusting for the local cost of living (COL index 92).
Cost of living comparisons use a base of 100 (US national average). Higher index = higher housing, transport, and consumer prices.
About Nurse Practitioner Salaries in St. Louis
The median nurse practitioner salary in St. Louis, MO is $120,000 for mid-level professionals, which is 2% above the national median. With a cost of living index of 92 (national average = 100), St. Louis offers an affordable cost of living, making these salaries stretch further.
Entry-level nurse practitioners in St. Louis can expect to earn between $87,000 and $112,000 (about $47.6/hour), while senior professionals with 6+ years of experience earn up to $166,000 ($166K annually, or about $79.81/hour).
These figures represent base salary only and do not include bonuses, equity, or benefits, which can add 20–50% to total compensation — especially at technology companies and in competitive markets like St. Louis.
Frequently Asked Questions: Nurse Practitioner Salary in St. Louis
What is the average Nurse Practitioner salary in St. Louis?+
The average Nurse Practitioner salary in St. Louis is $120,000 for a mid-level professional (3–5 years of experience). Entry-level pay starts around $99,000 and senior-level pay reaches $145,000.
How much does an entry-level nurse practitioner make in St. Louis?+
Entry-level nurse practitioners in St. Louis earn between $87,000 and $112,000, with a median of $99,000 per year (about $47.6/hour).
What is the hourly rate for a Nurse Practitioner in St. Louis?+
Based on a 2,080-hour work year, a Nurse Practitioner in St. Louis earns roughly $47.6/hour at entry-level, $57.69/hour at mid-level, and $69.71/hour at senior-level.
Is the Nurse Practitioner salary in St. Louis higher than the US average?+
Yes — Nurse Practitioner salaries in St. Louis are about 2% higher than the US national median of $118,000.
Does this include bonuses or equity?+
No — these figures are base salary only. Total compensation (base + bonus + equity + benefits) is typically 20–50% higher, and can be 2–3x at top technology and finance employers.
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